In the March issue of Phytopathology, Qian et al. show that LesR—a solo LuxR protein from the biocontrol agent Lysobacter enzymogenes—is involved in regulation of a heat-stable antifungal factor, acceleration of cell aggregation, and production of a melanin-like pigment. Solo LuxR proteins are quorum-sensing regulatory proteins that have developed the ability to sense exogenous N-acyl-homoserine lactone signals produced by neighboring bacteria. Qian et al.’s results suggest that chemical signaling between plant-associated bacteria can influence biological control activity in L. enzymogenes. Read Spanish and Chinese translations of this Editor’s Pick.