Using a simple population dynamic model, Mikaberidze et al. studied the impact of fungicide dosage on the evolution and establishment of fungicide resistance in plant pathogens and validated the findings with empirical data on Zymoseptoria tritici, the causal agent of Septoria leaf blotch of wheat. The authors conclude that using either the lowest rate that provides effective disease control or the highest or lowest labeled rate delays the development of fungicide resistance, and they recommend not using intermediate rates.  Open access.