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A truncated Xanthomonas oryzae TAL effector required for effector triggered immunity suppression in an American heirloom rice cultivar
Andrew Read: Cornell University; Lindsay Triplett: Connecticut Agricultural Experiment Station; Adam Bogdanove: Cornell University; Mathilde Hutin: Cornell University; Fabio Rinaldi: Cornell University; Yong-Qiang He: Guangxi Univ
<div><i>Xanthomonas oryzae </i>pv. oryzicola (Xoc) causes bacterial leaf streak (BLS) of rice. The first BLS resistance locus, Xo1, was recently identified from American heirloom rice cultivar Carolina Gold Select. Xo1 responds to many TAL effector variants resulting in robust effector triggered immunity (ETI). Although both African and Asian strains of Xoc encode and deliver TAL effectors that can be recognized, Xo1 only provides resistance to African strains. Our group recently demonstrated that the failure to elicit ETI by Asian strains is due to the delivery of a truncated TAL effector (truncTALE) by these strains resulting in suppression of resistance. Analysis of available sequence data revealed the presence of truncTALEs in most <i>X. oryzae</i> strains and noted conserved features that may be required for ETI suppression. We found that truncTALEs lack the hallmark DNA binding ability of full-length TAL effectors and do not appear to require a nuclear localization signal (NLS) to function. A study published shortly after ours found that the NLS is required for truncTALE suppression of bacterial blight resistance gene Xa1. Here we summarize our current knowledge of this novel class of effector and provide new insight into truncTALE sub-cellular localization and function. Further characterization of this ETI suppressing effector will guide resistance gene discovery and engineering efforts against truncTALE deploying Xanthomonas strains.</div>

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