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The molecular basis of vector competence in mosquito-arbovirus interactions.
L. C. BARTHOLOMAY (1). (1) Iowa State University, Ames, IA, U.S.A.

Although there are clear lessons to be learned from similarities in the molecular interactions between vectors and the viruses transmitted thereby, the potential research synergies in virus infections in insect-borne viruses of plants and animals are largely untapped. A distinct difference between vector-borne viruses is that the arthropod-borne viruses (arboviruses) of animals almost invariably depend on amplification in the vector for transmission, which is not the case for most vector-borne plant viruses. Even so, both plant and animal vector-borne viruses interact with, traverse, or infect and replicate in vector cells. It is increasingly clear that these interactions are not simple, benign events that go unnoticed by the vector. During infection with arboviruses including West Nile and Dengue (DENV), there is evidence for an active molecular arms race between virus replication and dissemination and the antiviral response in the mosquito; for example, DENV infection suppresses the Toll and Immunodeficiency (IMD) pathways, but the mosquito suppresses DENV, WNV and Sindbis virus infection with RNA interference (RNAi) and programmed cell death responses, particularly apoptosis. These innate immune responses are primary drivers for the compatibility of vector-arbovirus interactions and, therefore, of vector competence in blood-sucking arthropods.<p><p>Keywords:

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