Sensitivities of Venturia inaequalis isolates to the anilinopyrimidine fungicides (APs) pyrimethanil and cyprodinil were determined for nine populations by measuring the growth of colonies formed from germinating conidia derived from single scab lesions. At the discriminatory pyrimethanil dose of 0.2 μg ml-1, the mean relative growth range measured for eight V. inaequalis populations (n = 39 to 74) never treated with AP fungicides varied from 18.1 to 48.2, translating into an approximately sixfold difference in mean baseline sensitivities. For the composite of all 469 isolates tested, sensitivities to pyrimethanil and to the sterol demethylation inhibitor (DMI) myclobutanil were significantly correlated. When isolates were organized into subpopulations based on their sensitivities to an individual fungicide, sensitivities to both fungicides declined in parallel through the highly and moderately sensitive spectra of subpopulations, but they diverged for isolates in subpopulations least sensitive to either fungicide. The result suggested that at least one of the multiple genes conferring DMI resistance also lowered the sensitivity to AP fungicides. The relative contribution of AP fungicides to scab management was evaluated at an experimental orchard representative of the Great Lakes region of the United States. Frequencies of DMI-resistant isolates of V. inaequalis had progressed to the stage of practical resistance at the site, and the sensitivity to pyrimethanil was similar to several commercial orchard populations never treated with APs. For management programs at the experimental site involving the AP fungicides cyprodinil and pyrimethanil and conducted from 1996 to 2000, the level of fruit and terminal leaf scab control was inferior to that of nonspecific protectants such as mancozeb or captan. For the control of scab on cluster leaves, the efficacy of AP fungicides equaled the performance of nonspecific protectants. This modest contribution of AP fungicides to scab management might have been caused by a lack of the extended cool temperature conditions that were conducive to AP performance in northern Europe in previous studies, and/or by the reduced sensitivity to AP fungicides in this DMI-resistant V. inaequalis population.