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The Immunity Regulator BAK1 Contributes to Resistance Against Diverse RNA Viruses

November 2013 , Volume 26 , Number  11
Pages  1,271 - 1,280

Camilla Julie Kørner,1 Dominik Klauser,1 Annette Niehl,1 Ana Domínguez-Ferreras,1 Delphine Chinchilla,1 Thomas Boller,1 Manfred Heinlein,1,2 and Dagmar R. Hann1

1Zurich-Basel Plant Science Center, Department of Environmental Sciences, University of Basel, Hebelstrasse 1, 4056 Basel, Switzerland; 2Institut de Biologie Moléculaire des Plantes du CNRS, 12 Rue du Général Zimmer, 67000 Strasbourg, France

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Accepted 22 July 2013.

The plant's innate immune system detects potential biotic threats through recognition of microbe-associated molecular patterns (MAMPs) or danger-associated molecular patterns (DAMPs) by pattern recognition receptors (PRR). A central regulator of pattern-triggered immunity (PTI) is the BRI1-associated kinase 1 (BAK1), which undergoes complex formation with PRR upon ligand binding. Although viral patterns inducing PTI are well known from animal systems, nothing similar has been reported for plants. Rather, antiviral defense in plants is thought to be mediated by post-transcriptional gene silencing of viral RNA or through effector-triggered immunity, i.e., recognition of virus-specific effectors by resistance proteins. Nevertheless, infection by compatible viruses can also lead to the induction of defense gene expression, indicating that plants may also recognize viruses through PTI. Here, we show that PTI, or at least the presence of the regulator BAK1, is important for antiviral defense of Arabidopsis plants. Arabidopsis bak1 mutants show increased susceptibility to three different RNA viruses during compatible interactions. Furthermore, crude viral extracts but not purified virions induce several PTI marker responses in a BAK1-dependent manner. Overall, we conclude that BAK1-dependent PTI contributes to antiviral resistance in plants.

© 2013 The American Phytopathological Society