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Interactions Between Tobamovirus Replication Proteins and Cellular Factors: Their Impacts on Virus Multiplication

November 2010 , Volume 23 , Number  11
Pages  1,413 - 1,419

Kazuhiro Ishibashi, Masaki Nishikiori, and Masayuki Ishikawa

Division of Plant Sciences, National Institute of Agrobiological Sciences, Tsukuba 305-8602, Japan

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Accepted 30 June 2010.

Most viral gene products function inside cells in the presence of various host proteins, nucleic acids, and lipids. Thus, viral gene products come into direct contact with these molecules. The replication proteins of tobamovirus participate not only in viral genome replication but also in counterdefense mechanisms against RNA silencing and other plant defense systems. Accumulating evidence indicates that these functions are carried out through interactions with specific host components. Interactions with some cellular factors, however, are inhibitory to virus multiplication and contribute to host range restriction of tobamovirus. The interactions that have positive and negative impacts on virus multiplication should have been maintained and lost, respectively, during adaptation of the viruses to their respective natural hosts. This review lists the host factors that interact with the replication proteins of tobamovirus and discusses how they influence multiplication of the virus.

© 2010 The American Phytopathological Society