Mexico, is the leading producer of blackberries in the world with a yearly production of more than 240,000 tons. Fusarium wilt of blackberry, caused by Fusarium oxysporum species complex, is currently the most important disease of this crop because more than 2500 ha have been lost. The objective of this study was to determine the influence of soil physical and chemical variables on the intensity of the disease. During November 2017, 31 commercial plots of blackberry cv 'Tupy' were sampled in Los Reyes Valley, Michoacán, Mexico. At each site, a composite sample of soil was taken for further nutritional analysis. The incidence and disease severity was also estimated in each plot, and its geographical position, altitude, and the type of irrigation system used were recorded. In the laboratory, the quantification of CFU g-1 of soil per sample was estimated on Fusarium selective media. With the recorded variables, a Redundancy Analysis (RDA) was performed. The RDA analysis indicated that the variables that explained most of the variation in the incidence and severity of Fusarium wilt of blackberry were: the content of copper and magnesium (RDA1), the organic matter and sodium content (RDA2) and the electrical conductivity, boron and iron content (RDA3). Organic matter, iron content magnesium, and copper content were also correlated with the UFC density in the soil as well. These studies will contribute to reducing the risk factors that influence the intensity of Fusarium wilt of blackberry epidemics in Mexico.