Marrone Bio Innovations (MBI), based in Davis California, is an industry leader in developing natural biostimulants and biopesticide products. For the past 11 years, the company has developed and commercialized a broad portfolio of products that includes Fungicides, Insecticides, Nematicides and Plant health products. These bio- and plant- based products are approved for virtually every cultivated crop, from fruits and vegetables to cereal grains and nuts, from turfgrass and flowers to alfalfa and cotton. These products are organic-compliant and when incorporated into an IPM (Integrated Pest Management) program, they can be an effective solution to pest control problems in conventional, transitional or certified organic production systems. The formulation effort not only involved foliar and soil application but also seed treatment for protection against pests as well providing plant growth and yield enhancement. This presentation will discuss the complex multidisciplinary approach involving microbiology, chemistry, fermentation, formulation and plant sciences to screen bioactive ingredients and develop them into products through scale up and manufacturing. Various case studies involving liquid and solid formulations will be presented along with the challenges associated with stability, processing, efficacy and delivery of the product. Application studies involving the effects from field such as pH, water hardness, temperature, adjuvant and chemical tank mixes and their impact on the performance of the product will be discussed.