Sudden Death Syndrome (SDS) is among the top soybean yield reducing diseases in the United States. First discovered in Arkansas in 1971, SDS has recently spread to become a much greater disease problem beyond the Mid-South region. Encouraged by cooler, wetter conditions early, Fusarium virguliforme, the pathogen that causes SDS, infects young developing root systems. Plant parasitic nematodes, especially Soybean Cyst Nematode, exacerbate SDS infection, symptomology and yield loss. Juvenile nematodes enter developing roots damaging them and leaving them more susceptible to Fusarium virguliforme colonization as well as plant stress caused by the nematode and SDS. The Syngenta Crop Protection Seedcare business expects a new seed-applied molecule, Adepidyn®, to be registered by the US EPA in Q3 2019. Adepidyn is effective against SDS by protecting against Fusarium virguliforme and providing soybean roots protection against important plant parasitic nematodes. In multi-year field tests, Saltro®, with the active ingredient Adepidyn, delivered a statistically significant (P = 0.1) +3 Bu/Ac yield advantage over the leading competitor under heavy SDS. Additionally, adepidyn has proven extremely safe in terms of seed and plant safety, exhibiting no negative plant response or phytotoxicity symptomology exhibited by the leading SDS solution. In the near future, Saltro will provide soybean growers a strong tool for both SDS and nematode protection.