Fusarium graminearum is an important soilborne and seedborne pathogen that causes reduced emergence and seedling blight of row crops. The use of seed-applied fungicides is one major management strategy; however, it is constrained by several factors including rapid dissipation of active ingredients, limiting uptake in plant tissues, and absorption by target organisms. Our research investigates improving the efficacy of seed-applied active ingredients through the use of polyanhydride polymers. These polymers have been extensively studied in other systems to facilitate time-release of active compounds. The surface-erosion mechanism of polyanhydride particles promotes a sustainable and predictable release of active ingredients encapsulated in polyanhydride nanoparticles. We hypothesized that nanoencapsulation of commonly-used fungicides could prolong the release due to the slow degradation rate of this nanoparticle coating and hence, improving control of F. graminearum. In-vitro efficiency assays using systemic and contact seed treatment fungicides, thiabendazole and fludioxonil, were conducted. For some active ingredients, encapsulated formulations resulted in lower disease severity, and an increase in healthy biomass compared to the standard formulation.